目的 分析2012—2021年宝山区非免疫规划（national immunization program，NIP）疫苗的接种情况，为加强非NIP疫苗管理和接种提供参考。方法 通过上海市疫苗接种率数据库和上海市预防接种信息系统收集2012—2021年宝山区非NIP疫苗接种数据，并进行描述性流行病学分析。运用Mann-Kendall检验进行趋势分析，运用卡方检验分析不同地区间接种情况差异，检验水准α=0.05。结果 2012—2021年宝山区非NIP疫苗共接种263.73万剂，人均接种剂次1 281.66剂/万人，接种剂次和接种占比均总体呈上升趋势。年均接种剂次位居前5位的分别为狂犬病疫苗、流感疫苗、人乳头瘤病毒疫苗、肠道病毒71型疫苗和A 群C 群脑膜炎球菌多糖结合疫苗。宝山区城乡之间非NIP疫苗接种占比差异具有统计学意义（χ²=22 140.20，P＜0.001）。所有替代类非NIP疫苗的替代率从2012年的12.12%上升到2021年的26.80%。结论 宝山区非NIP疫苗的接种剂次和接种占比总体呈上升趋势，仍需加强疫苗接种监测和使用管理，加强疫苗相关知识宣传和普及，提高预防接种门诊服务能力，进一步提高非NIP疫苗接种率。

Objective To analyze the vaccination status of non-national immunization program (non-NIP) vaccines in Baoshan District from 2012 to 2021, and provide references for strengthening non-NIP vaccine management and vaccination.Methods Non-NIP vaccination data in Baoshan District from 2012 to 2021 were collected through the Shanghai Vaccination Rate Database and the Shanghai Vaccination Information System, and descriptive epidemiological analysis was conducted. Mann-Kendall test was used for trend analysis, and chi-square test was used to analyze the difference of vaccination among different regions, with a test level of α = 0.05.Results From 2012 to 2021, 2.637 3 million doses of non-NIP vaccines were vaccinated in Baoshan District, with an average vaccination rate of 1 281.66 doses per 10 000 population. The number of doses and the proportion of vaccinations showed an overall upward trend. The top five vaccines in average annual vaccination rate were rabies vaccine, influenza vaccine, human papillomavirus vaccine, enterovirus type 71 inactivated vaccine，group A and C meningococcal polysaccharide conjugate vaccine. The difference in the proportion of non-NIP vaccination between urban and rural areas in Baoshan District was statistically significant (χ²= 22 140.20, P < 0.001). The substitution rate of all alternative non-NIP vaccines increased from 12.12% in 2012 to 26.80% in 2021.Conclusions The number of doses and proportion of non-NIP vaccines in Baoshan District are generally on the rise. It is still necessary to strengthen vaccination monitoring and use management, strengthen the publicity and popularization of vaccine-related knowledge, improve vaccination outpatient service capabilities, and further increase the non-NIP vaccination rate.