嗜肺军团菌是军团菌肺炎的致病菌。随着军团菌肺炎的流行，疫苗的研发日渐迫切。此文综述了自1976年军团菌肺炎首次暴发以来有关嗜肺军团菌疫苗研发的现状和成果，着重介绍了重组蛋白疫苗、核酸疫苗和表位疫苗3类具有较大应用前景的疫苗，并对各类疫苗的优点和局限性进行了简要的评述，同时提出了研究嗜肺军团菌疫苗的新思路。

Legionella pneumophila is the pathogen of Legionella pneumonia. With the prevalence of Legionella pneumonia, the research and development of vaccines is increasingly urgent. This paper summarizes the status and achievements of vaccine development since the initial outbreak of Legionella pneumonia in 1976. This paper highlights three major vaccines with greater application prospects, including the recombinant protein vaccine, nucleic acid vaccine and epitope vaccine. Meanwhile, the advantages and shortcomings of various Legionella pneumophila vaccines are briefly reviewed, and some new ideas for the research of Legionella pneumophila vaccine are proposed.