人巨细胞病毒诱导癌变的机制研究新进展

朱嘉怡; 侯伟; 张乐谦; 张俊玲; 薛莲; 王琦; 王明丽

doi:10.3760/cma.j.cn311962-20231107-00016

国际生物制品学杂志 >

2024 , Vol. 47 >Issue 5: 325 - 330

DOI: https://doi.org/10.3760/cma.j.cn311962-20231107-00016

综述

人巨细胞病毒诱导癌变的机制研究新进展

朱嘉怡 ,
侯伟 ,
张乐谦 ,
张俊玲 ,
薛莲 ,
王琦 ,
王明丽

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¹安徽医科大学第二临床医学院，合肥 230032； ²安徽医科大学中央与地方共建生物医学工程实验室，合肥 230032； ³芜湖天明生物技术有限公司，芜湖 241000； ⁴安徽医科大学微生物学教研室，合肥 230032； ⁵安徽医科大学临床医学院，合肥 230031

网络出版日期: 2025-08-16

基金资助

安徽省教育厅2020年高等学校省级质量工程项目(2020xsxxkc249)；安徽医科大学博士科研资助基金(XJ202001)；安徽高校自然科学研究重点项目(KJ2020A0141)

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New advances in the research on mechanisms of human cytomegalovirus-induced carcinogenesis

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¹ The Second Clinical Medical College, Anhui Medical University, Hefei 230032, China；² Central and Local Biomedical Engineering Laboratories, Anhui Medical University, Hefei 230032, China；³ Wuhu Tianming Biotechnology Co., Wuhu 241000, China；⁴Department of Microbiology, Anhui Medical University, Hefei 230032, China；⁵ Clinical Medicine College, Anhui Medical University, Hefei 230031, China

Online published: 2025-08-16

Supported by

Anhui Province Department of Education 2020 Provincial Engineering Project for Higher Education Institutions (2020xsxxkc249); Doctoral Research Fund of Anhui Medical University (XJ202001); Natural Science Research Project of High Institutions in Anhui (KJ2020A0141)

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摘要

癌症是世界范围内的主要致死疾病之一，至今病因和发病机制仍不甚清楚。人巨细胞病毒（human cytomegalovirus，HCMV）属于疱疹病毒，感染后可编码多种致癌基因，还可激活多条癌症相关的重要信号通路，启动相关癌症的发生与发展。对乳腺癌、胶质母细胞瘤和肌肉肉瘤等的研究结果报告为上述论断提供了重要证据。此文就HCMV感染后诱导癌变的相关分子机制和临床研究成果进行综述，以期为HCMV感染的临床预防和治疗提供新思路与新靶点。

关键词： 巨细胞病毒；信号通路；肿瘤；多倍体巨型癌细胞；胶质母细胞瘤；乳腺肿瘤；肌肉肉瘤

本文引用格式

朱嘉怡 , 侯伟 , 张乐谦 , 张俊玲 , 薛莲 , 王琦 , 王明丽 . 人巨细胞病毒诱导癌变的机制研究新进展[J]. 国际生物制品学杂志, 2024 , 47(5) : 325 -330 . DOI: 10.3760/cma.j.cn311962-20231107-00016

Abstract

Cancer is one of the leading causes of death worldwide, and its etiology and pathogenesis are still not well understood. Human cytomegalovirus (HCMV) is a type of herpesvirus that encodes multiple oncogenes, activates various important signaling pathways related to cancer, and promotes cancer initiation and development after infection. Studies on breast cancer, glioblastoma, and muscle sarcoma etc have provided important evidence in this regard. This article reviews the molecular mechanisms and clinical researches of HCMV-induced carcinogenesis, aiming to provide new insights and targets for clinical prevention and treatment of HCMV infection.

Key words： Cytomegalovirus; Signaling pathway; Neoplasms; Polyploid giant cancer cells; Glioblastoma; Breast neoplasms; Muscle sarcomas

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