铁死亡在自身免疫性疾病中的研究进展

张欣薇; 江妍斐; 张进安

doi:10.3760/cma.j.cn311962-20230225-00020

国际生物制品学杂志 >

2024 , Vol. 47 >Issue 1: 49 - 55

DOI: https://doi.org/10.3760/cma.j.cn311962-20230225-00020

综述

铁死亡在自身免疫性疾病中的研究进展

张欣薇 ,
江妍斐 ,
张进安

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1上海中医药大学研究生院，上海 201203；2上海健康医学院附属周浦医院内分泌-风湿科，上海201318；3上海中医药大学，上海 201203

网络出版日期: 2025-08-16

基金资助

上海市浦东新区卫健委“浦东新区第二轮医学学科建设项目-临床特色学科” （PWYts2021-09）；浦东新区卫生系统优秀青年医学人才培养计划（PWRq2022-34）；上海健康医学院甲状腺病临床研究中心（20MC20200002）

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Ferroptosis in autoimmune diseases

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1Graduate School, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; 2Depertment of Endocrinology, Shanghai University of Medicine ＆ Health Science Affiliated Zhoupu Hospital, Shanghai 201318, China; 3Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China

Online published: 2025-08-16

Supported by

Shanghai Pudong New Area Health Committee "Pudong New Area Second Round Medical Discipline Construction Project - Clinical Specialties" (PWYts2021-09); Pudong New Area Health System Excellent Young Medical Talent Training Program (PWRq2022-34); Clinical Research Center of Thyroid Diseases of Shanghai University of Medicine ＆ Health Sciences (20MC20200002)

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摘要

铁死亡作为一种独特的调节性细胞死亡形式，其特征是铁依赖的脂质过氧化物的清除受损或过度产生导致其积累达到致死水平。近年来铁死亡在临床疾病领域的研究成为了热点，在自身免疫性疾病中的研究也逐渐增多。此文就铁死亡的重要概念、调控机制以及铁死亡在几种常见自身免疫性疾病的作用进行综述。

关键词： 铁死亡；自身免疫疾病；谷胱甘肽过氧化物酶4；关节炎，类风湿；红斑狼疮，系统性

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张欣薇 , 江妍斐 , 张进安 . 铁死亡在自身免疫性疾病中的研究进展[J]. 国际生物制品学杂志, 2024 , 47(1) : 49 -55 . DOI: 10.3760/cma.j.cn311962-20230225-00020

Abstract

As a unique form of regulatory cell death, ferroptosis is characterized by impaired clearance or excessive production of iron-dependent lipid peroxides resulting in their accumulation to lethal levels. In recent years, ferroptosis has become a hot topic in the field of clinical diseases. Researches on the relationship between ferroptosis and autoimmune diseases are gradually increasing. This paper reviews the important concepts, regulatory mechanisms and the role of ferroptosis in several common autoimmune diseases.

Key words： Ferroptosis; Autoimmune disease; Glutathione peroxidase 4; Arthritis, rheumatoid; Lupus erythematosus, systemic

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