疫苗是预防控制传染性疾病的最有效手段，传染性疾病中约80%是由病毒引起的。传统的病毒类疫苗需要经过病毒培养、抗原收获、抗原浓缩、纯化过滤等过程制备而成。由于病毒的生长和繁殖必须在细胞内进行，因此细胞基质的优劣直接影响疫苗的质量。此文对各类细胞基质使用情况及优缺点进行综述，旨在为选择合适的人用疫苗生产用细胞基质提供参考。

Vaccine is the most effective way to prevent and control infectious diseases. Approximately 80% of infectious diseases are viral diseases. The traditional viral vaccines are prepared by virus cultivation, antigen harvest, antigen concentration, purification and filtration process. Since the growth and reproduction of viruses must take place in the cells, the quality of the cell substrates directly affects the quality of the vaccine products. This article reviews the current status of various cell substrates and discuss their advantages and disadvantages, aiming to provide a reference for choosing the appropriate cell substrate for human vaccine production.