Autoimmunity induced by SARS-CoV-2 infection
1Department of Medical Biodefence, Faculty of Naval Medicine, Naval Medical University, Shanghai 200433, China;2School of Basic Medical Sciences, Naval Medical University, Shanghai 200433, China
Online published: 2025-08-16
新型冠状病毒(severe acute respiratory syndrome coronavirus 2,SARS-CoV-2)感染不仅严重影响人体免疫,而且可能诱发易感人群的自身免疫病。此文对SARS-CoV-2感染者体内产生的5大类自身抗体以及这些自身抗体可能导致的自身免疫病、患者自身免疫系统过度激活的相关研究进展,以及其诱导机体自身免疫的可能机制进行综述,以期为SARS-CoV-2相关的自身免疫性损伤与疾病的研究提供理论基础。
关键词:
新型冠状病毒;自身抗体;自身免疫病
陈奕孛 , 陈梦棣 , 苗根 , 戚中田 , 丁翠玲 . 新型冠状病毒感染诱导的机体自身免疫[J]. 国际生物制品学杂志, 2023 , 46(1) : 13 -18 . DOI: 10.3760/cma.j.cn311962-20220518-00027
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection not only seriously affects human immunity, but also may induce autoimmune diseases in genetically susceptible people. The research progresses of five major types of autoantibodies produced in SARS-CoV-2 infected patients, the autoimmune diseases that may be caused by autoantibodies, the excessive activation of the patients’ autoimmune system, and the possible mechanisms that autoimmunity induced by SARS-CoV-2 infection were summarized in this review, which aims to provide a theoretical basis for the study of SARS-CoV-2-related autoimmune injury and diseases.
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