目的  探讨冻干制剂乙型脑炎减毒活疫苗和液体制剂23价肺炎球菌多糖疫苗0～2 ℃条件下存放对其效价的影响。方法  将冻干制剂乙型脑炎减毒活疫苗和液体制剂23价肺炎球菌多糖疫苗存放于0～2 ℃条件下一定时间后，与存放于2～8 ℃规定条件的制品进行疫苗效价的比较。结果  1人份和5人份乙型脑炎减毒活疫苗在0～2 ℃条件下分别存放17 h 20 min和18 h 55 min，病毒滴度均符合5.7～7.1 lgPFU/ml的质量标准，且与存放于2～8 ℃规定条件的同批次疫苗比较，t值分别为0.26和0.28，P值均大于0.05，差异无统计学意义；23价肺炎球菌多糖疫苗在0～2 ℃条件下存放21 h 50 min，23个型别的多糖含量均符合35～65 μg/ml的质量标准，且与存放于2～8 ℃规定条件的同批次疫苗比较，t值为0.01~2.25，P值均大于0.05，差异无统计学意义。结论  冻干制剂乙型脑炎减毒活疫苗和液体制剂23价肺炎球菌多糖疫苗存放在0～2 ℃条件下的一定时间内，疫苗效价仍符合质量标准。

Objective  To investigate the effect on their potencies of lyophilized live attenuated Japanese encephalitis vaccine and liquid 23-valent pneumococcal polysaccharide vaccine when stored at 0-2 ℃. Methods  The potencies of lyophilized live attenuated Japanese encephalitis vaccine and liquid 23-valent pneumococcal polysaccharide vaccine stored at 0-2 ℃ after certain time were compared with same batch vaccines stored at 2-8 ℃. Results  Lyophilized live attenuated Japanese encephalitis vaccines of 1-dose and 5-dose were stored at 0-2 ℃ for 17 h 20 min and 18 h 55 min，respectively. The viral titers of 1-dose and 5-dose vaccines both met the quality standard of 5.7-7.1 lgPFU/ml, and the t values between titers of the same batch vaccines stored at 0-2 ℃ and 2-8 ℃ were 0.26 and 0.28, respectively, with P values > 0.05, and there was no statistically significant difference. The 23-valent pneumococcal polysaccharide vaccine was stored at 0-2 ℃ for 21 h 50 min. The polysaccharide contents of all 23 types met the quality standard of 35-65 μg/ml, and the t values between polysaccharide contents of the same batch vaccines stored at 0-2 ℃ and 2-8 ℃ were 0.01-2.25 with P value > 0.05, and there was no statistically significant difference. Conclusion  The potencies of lyophilized live attenuated Japanese encephalitis vaccine and liquid 23-valent pneumococcal polysaccharide vaccine still meet the quality standard after store at 0-2 ℃ for a certain time.