1安徽医科大学第二临床医学院，合肥 230032；2安徽医科大学中央与地方共建生物医学工程实验室，合肥 230032；3芜湖天明生物技术有限公司研发部,芜湖 241000；4安徽医科大学微生物学教研室，合肥 230032；5广州金域医学检验集团研究中心，广州 510005；6安徽医科大学临床医学院，合肥 230032
网络出版日期: 2025-08-16
基金资助
安徽省教育厅2020年高等学校省级质量工程项目（2020xsxxkc249）；安徽医科大学博士科研资助基金（XJ202001）；安徽高校自然科学研究重点项目（KJ2020A0141）
The immune function of dendritic cell and its new research progress
1 The Second Clinical Medical College, Anhui Medical University, Hefei 230032, China; 2Central and local Biomedical Engineering Laboratories, Anhui Medical University, Hefei 230032, China; 3R&D Department, Wuhu Tianming Biotechnology Co., Ltd., Wuhu 241000, China; 4 Department of Microbiology, Anhui Medical University, Hefei 230032, China; 5Research Center, Guangzhou Kingmed Diagnostics Group Co., Ltd., Guangzhou 510005, China; 6Clinical Medical College, Anhui Medical University, Hefei 230032, China
Online published: 2025-08-16
Supported by
Anhui Provincial Department of Education 2020 Provincial Quality Engineering Project for Higher Education Institutions（2020xsxxkc249）；Anhui Medical University Doctoral Research Fund（XJ202001）；Anhui University Natural Science Research Key Project(KJ2020A0141）
树突状细胞（dendritic cell，DC）是一种专职APC，来源于造血干细胞。近年来的研究发现，DC能高效摄取、加工、呈递抗原。其中，未成熟DC具有较强的迁移能力；成熟DC能有效激活初始T细胞，适时适度地启动机体的适应性免疫应答。此文综述DC的起源、分化与特征和免疫调节能力，同时回顾DC在肿瘤、动脉粥样硬化和巨细胞病毒感染等疾病中的重要研究进展。
陈杰 何浩 许智勇 蒋敏之 吴博 张俊玲 何茂章 陈敬贤 王明丽 . 树突状细胞的免疫功能及其研究新进展[J]. 国际生物制品学杂志, 2022 , 45(3) : 169 -174 . DOI: 10.3760/cma.j.cn311962-20211129-00079
Dendritic cell (DC) is a kind of professional APC originating from hematopoietic stem cell. Researches have found that DC can efficiently ingest, process and present antigen to other immune cells. Immature DCs have strong migration ability while mature DCs effectively activate naive T cell and induce immune responses timely and moderately. This article reviews the origin, differentiation, characteristics and immunomodulatory capabilities of DC, as well as important current development in the research of DC in tumor treatment and inhibition of inflammatory disease such as atherosclerosis and cytomegalovirus infection.
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