目的  研究两种狂犬病疫苗免疫程序对抗体效价的影响。方法  将献血浆者按照基础免疫剂量分成两组，第1组初次免疫2剂，第2次、第3次各免疫1剂；第2组初次、第2次、第3次均免疫1剂；两组间隔时间一致。在初次免疫后第14、28、42、56、70、84天，检测献血浆者血浆中的狂犬病抗体效价，考察是否符合单人份生产用原料血浆抗体效价标准（≥8 IU/ml）。结果  初次免疫后第14、28、42天，第1组献血浆者抗体阳转率更高，差异具有统计学意义（c²值分别为4.65、8.69、4.11，P＜0.05）；仅在初次免疫后14 d内，第1组抗体效价≥8 IU/ml的比例更高，差异具有统计学意义（c²=5.45，P＜0.05）；距初次免疫第56、70、84天两组血浆抗体效价差异不具有统计学意义（P＞0.05）。结论  在免疫程序期间，大剂量的狂犬病疫苗免疫程序能取得较好的免疫应答效果，但在长期抗体水平方面与小剂量注射程序无明显差异。

Objective  To study the effect of rabies vaccine immunization programs with different doses on antibody titers. Methods  The plasma donors were divided into two groups according to the primary immunization dosage. The first group was immunized with two doses at the first time, and one dose at both second and third times. The second group was immunized with one dose at the first, second, and third times. The two groups have the same interval. The titer of rabies antibody in plasma was detected on day 14, 28, 42, 56, 70, and 84 after the first immunization. Result  On day 14, 28, and 42 after the first immunization, the first group obtained statistically significantly  (c² values were 4.65, 8.69, 4.11, respectively, all P<0.05) higher antibody positive conversion rate. As for the antibody titer standard of single source plasma for blood products (≥ 8 IU/ml), the difference was statistically significant only within 14 days after the first immunization (c²=5.45, P<0.05) .There was no significant difference in antibody titer between the two groups on days 56, 70, and 84 (P>0.05). Conclusion  Rabies vaccine immunization program with high dose can achieve better immune response effect during the program, but there is no significant difference in the long-term antibody level between high and low dosage immunization program.