人胰高血糖素样肽1（glucagon-like peptide-1，GLP-1）是治疗2型糖尿病的主要药物，其长效性是一个重要指标。GLP-1化学合成工艺复杂、成本较高，因此通过基因工程获得重组长效GLP-1类似物成为目前的研究方向。此文对近年来通过基因工程获得重组长效GLP-1类似物的研究进行综述。

Human glucagon-like peptide1 (GLP-1) is the main medication for type 2 diabetes treatment  and its long-term effectiveness is an important indicator. Since chemical synthesis of GLP -1 is complicated and costly, genetic engineering to obtain recombinant long-acting GLP-1 analogs  has been the current research direction. This article reviews recent studies on recombinant long-acting human GLP-1 analogs by genetic engineering.