抗凝血酶Ⅲ（antithrombin Ⅲ，AT-Ⅲ）是人血浆中的一种多功能丝氨酸蛋白酶抑制蛋白，也是血液中的重要抗凝血因子，在生理性凝血机制中起重要作用。先天性或获得性AT-Ⅲ缺乏可导致血栓发生。临床上主要应用AT-Ⅲ 浓缩制剂防治血栓栓塞性疾病。此文就AT-Ⅲ在人体中的主要功能以及在临床治疗中的作用做简要综述。

 Human antithrombin Ⅲ （AT-Ⅲ） is a multifunctional serine protease inhibitor in human plasma as well as an important anticoagulant factor in blood, which plays an important role in the physiological coagulation mechanism. Congenital and acquired deficiency of AT-Ⅲ can induce thrombosis. AT-Ⅲ concentrated preparations are mainly used to prevent and treat thromboembolic diseases. This review summarizes the major functions of AT-Ⅲ in human body and its role in the clinical treatment.