T细胞受体（T cell receptor，TCR）是T细胞识别抗原和诱导免疫应答的基础。在自身免疫病状态下，T细胞根据疾病特异性抗原可产生相应的特异性TCR库的克隆扩增。通过高通量分子测序技术检测TCR序列，找出疾病状态下和健康人中TCR库的差异，可进一步探索疾病的发病机制，并为进一步通过诱导免疫耐受干预疾病的发生发展提供了可能。此文概述了近5年来TCR测序和自身免疫病之间的原始研究，并对相关研究进展进行了总结。

T cell receptor (TCR) is the basic structure for T lymphocyte to recognize variable antigens and induce immune response. In the state of autoimmune disease, specific clones of T cells with corresponding TCR repertoire are amplified based on the specific antigens of the disease. Detection of TCR sequences by high-throughput sequencing technology and identification of TCR repertoire differences between patients and healthy people are novel methods to explore the pathogenesis of diseases. More importantly, it provides a possibility to prevent the initiation and development of diseases through inducing immune tolerance. This review covers the original studies about TCR sequencing in autoimmune diseases in the past 5 years, and summarizes its research progress.