人表皮生长因子受体3（human epidermal growth factor receptor 3，Her3/ ErbB3）是人表皮生长因子受体家族的一员，能通过配体依赖或非配体依赖的二聚化，激活并调节下游信号通路。目前Her3已成为非小细胞肺癌、乳腺癌等肿瘤治疗非常有潜力的候选靶点。但是，由于缺乏有效的生物标志物，不能针对Her3靶点筛选适应证患者，所以针对Her3的研究存在一定的局限性。此文综述了对Her3靶点的探究以及当前Her3靶向Her3治疗的研究进展。

Human epidermal growth factor receptor (Her)3/ ErbB3 is a member of the Her family, which can activate and regulate downstream signaling pathways by ligand-dependent or non-ligand-dependent dimerization. At present, Her3 has become a potential target for the treatment of non-small cell lung cancer, breast cancer, etc. However, the suitable patients can not be screened by Her3 target due to the lack of effective biomarker, so there are certain limitations for Her3 research. This paper reviews the exploration of Her3 target and research progress in Her3 targeting-therapy.