细胞因子类生物制品是一种细胞分泌的具有生物活性的小分子蛋白质，其活性在生产和储存阶段受到众多因素影响。目前其稳定性的研究要求除了通过制品本身特性（诸如物理化学特性）以及制品外界环境进行外，正在从多个方面、结合各种相关因素的综合作用来考虑其稳定性的维持，包括不同分子结构改造方式、稳定剂的优化研究、制品的蛋白质微囊化、液体制剂的稳定性优化和包装容器的合理选择等。

Cytokine biologicals are small proteins with biological activities secreted from the cells, whose stability are affected by many factors during the manufacturing and storage phases. Cytokine stability research is not only based on its basic characters (physical and chemical properties) and its environment, but also on comprehensive effects of different relevant factors, including structural modification of protein molecules, optimization of stabilizer, cytokine microcapsulation, improving stability of liquid preparation, and proper choice of packaging containers.