肠道病毒71型（enterovirus 71，EV71）是手足口病的主要病原体，由于尚无治疗手足口病的有效抗病毒药，因此，开发预防手足口病的有效EV71疫苗成为所有控制措施的首选。目前，EV71疫苗研究已取得一定的进展，正在研发的疫苗包括减毒或灭活疫苗、VP1亚单位疫苗和 DNA疫苗。虽然各种疫苗均具有一定的免疫效果，但最适疫苗的确认还需对各种疫苗的安全性和保护效力进行评估。

Enterovirus 71 (EV71) is a major etiological agent of hand-foot-and-mouth disease (HFMD).Since no effective antiviral agents are available,developing effective EV71 vaccines for prevention of HFMD has been the control measure of choice. Currently, the research of EV71 vaccines has made certain progress,and various EV71 vaccines,including attenuated vccines, inactivated vaccine,VP1 subunit vaccine and DNA vaccine, are being developed.Although various EV71 vaccines have certain efficacy,the optimal vaccine needs to be identified by evaluating the safety and protective efficacy of various EV71 vaccines.