在近20年，针对程序性死亡分子1和细胞毒性T细胞相关抗原4等抑制性受体的抗体药物一直是研究热点。抑制性受体通路（免疫检查点）在正常情况下维持免疫内稳态，防止免疫细胞过度激活，但肿瘤可以通过抑制性受体通路来逃避免疫细胞杀伤。抗体药物可阻断抑制性信号通路，进而活化免疫细胞杀伤肿瘤细胞。此文对抗抑制性受体抗体药物的最新进展进行综述。

  In the past 20 years, antibodies against programmed death-1 and cytotoxic lymphocyte-associated antigen-4 have been research. Normally, inhibitory receptor pathway (immune checkpoint) maintains immunologic homeostasis and prevents excessive activation of immune cells. However, tumors can escape immune cell killing through this pathway. Antibody drugs can block the inhibitory signal pathway and activate immune cells to kill tumor cells. This article reviews the recent progress of antibody drugs against inhibitory receptors.