目的  了解郑州某高校新生对两种国产乙型肝炎（乙肝）疫苗预防接种的效果。方法  采用随机抽样方法，抽取743名新生分为两组，分别接种重组乙肝疫苗（CHO细胞）和重组乙肝疫苗（汉逊酵母），剂量均为10μg/0.5ml, 按0、1、6个月免疫程序接种，免疫后2个月，检测血清抗-HBs滴度，比较两种疫苗的抗体阳转率和几何平
均浓度（GMC）。结果  重组乙肝疫苗（CHO细胞）组的抗体阳转率为87.14%，重组乙肝疫苗（汉逊酵母）组的抗体阳转率为97.20%。两组疫苗的抗-HBs GMC分别为1489.72和2265.68 mIU/ml。 结论  国产重组乙肝疫苗（汉逊酵母）预防接种效果良好，应大力 推广使用。

Objective  To evaluate immunization effects of two kinds of domestic recombinant hepatitis B vaccines in college freshmen.  Methods  Randomized sampling was adapted in this study. A total of 743 freshmen were divided into recombinant hepatitis B vaccine (CHO cell) group and recombinant hepatitis B vaccine (Hansenula polymorpha) group, and the freshmen in each group were immunized with 3 doses of the corresponding vaccine 10 μg/0.5 ml at a schedule of 0, 1, and 6 months. Serum anti-HBs titer was measured 2 months after the last vaccination, and antibody positive rates and GMC were compared between the two groups.  Results  Antibody positive rates were 87.14% in recombinant hepatitis B vaccine (CHO cell) group and 97.20% in recombinant hepatitis B vaccine (Hansenula polymorpha) group, and anti-HBs GMC was1489.72 and 2265.68 mIU/ml,respectively.  Conclusion  The effects of recombinant hepatitis B vaccine (Hansenula polymorpha) is prominent, which can be used widely.