综述

肠道病毒71型感染诱导细胞凋亡的途径和分子机制

  • 赵恒 李琦涵
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  • 650031 昆明医学院基础医学院生物化学与分子生物学教研室(赵恒);650118 昆明,中国医学科学院生物学研究所病毒免疫室(赵恒、李琦涵)

网络出版日期: 2025-08-16

The pathways and molecular mechanisms of apoptosis induced by EV71 infection

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  • *Department of Biochemistry and Molecular Biology, School of Basic Medical Science, Kunming Medical university; Department of Viral Immunology, Institute of Medical Biology, Chinese Academy of Medical Science,Kunming 650118, China

Online published: 2025-08-16

摘要

肠道病毒71型(enterovirus 71,EV71)主要感染5岁以下儿童,是手足口病的主要病原体之一。由于EV71具有高度的嗜神经性,因此,EV71感染能并发严重的神经系统疾病,包括致死性脑炎、无菌性脑膜炎、脑脊髓炎。此文就EV71诱导细胞凋亡的途径和分子机制进行综述。

本文引用格式

赵恒 李琦涵 . 肠道病毒71型感染诱导细胞凋亡的途径和分子机制[J]. 国际生物制品学杂志, 2011 , 34(3) : 156 -159 . DOI: 10.3760/cma.j.issn.1673-4211.2011.03.011

Abstract

 Enterovirus 71(EV71) principally infects the children under 5 years old, and is one of the major causes of hand, foot and mouth disease. Because EV71 is highly neurotropic, EV71 infection can cause severe neurological complications, including fatal encephalitis, aseptic meningitis and encephalomyelitis. In this paper, the apoptosis pathways induced by EV71 and their molecular mechanisms are reviewed.
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