肿瘤的生长、侵袭和迁移依赖于血管新生。因此，以抑制肿瘤血管形成为目标的抗肿瘤治疗策略是当前研究的热点。血管内皮生长因子及其受体在肿瘤血管新生这一病理性血管形成过程中起关键作用，从而使它们成为研发肿瘤疫苗的靶点。此文就疫苗的研发基础、免疫机制及研究进展做一综述。

Tumor growth, invasion and migration depend on angiogenesis. Therefore, the anti-tumor therapeutic strategy targeting tumor angiogenesis is currently a research focus. Vascular endothelial growth factor (VEGF) and its receptor (VEGFR) play critical roles in the process of tumor angiogenesis, which makes VEGF/VEGFR become targets for research and development of tumor vaccines. This article summarizes research principle, immune mechanism and research progress of these vaccines.