综述

胃癌中靶向蛋白激酶B通路的研究进展

  • 徐扬 施维
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  • 130012 长春,吉林大学分子酶学工程教育部重点实验室,生命科学学院

网络出版日期: 2025-08-16

Research progress of targeting protein kinase B pathway in gastric cancer

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  • Key Laboratory for Molecular Enzymology and Engineering, Ministry of Education, Life Science College, Jilin University, Changchun 130012, China   

Online published: 2025-08-16

摘要

蛋白激酶B(protein kinase B,PKB,又称AKT)通路的过度活化是胃癌发病、转移以及化疗耐药的主要原因。此文对胃癌与AKT通路的关系以及靶向抑制AKT通路的发展现状和前景做一综述。

本文引用格式

徐扬 施维 . 胃癌中靶向蛋白激酶B通路的研究进展[J]. 国际生物制品学杂志, 2012 , 35(6) : 321 -323 . DOI: 10.3760/cma.j.issn.1673-4211.2012.06.010

Abstract

 The activation of protein kinase B (PKB/AKT) pathway is the main reason of development, metastasis and chemotherapy resistance of gastric cancer. In this paper, the relationship between AKT pathway and gastric cancer and AKT pathway-targeting therapy are reviewed.
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