对禽流感病毒（avian influenza virus，AIV）致病性的研究已取得了一定进展。AIV的致病性主要与血凝素、神经氨酸酶、RNA聚合酶和非结构蛋白的编码基因突变导致氨基酸变化有关，而且，AIV的致病性是多个编码基因共同作用的结果。

Some progress has been made in the research of pathogenicity of avian influenza virus. The pathogenicity is associated with the change of amino acids in hemagglutinin, neuraminidase, RNA polymerase and non-structural protein caused by gene mutation, and furthermore, it is the result of co-action of different genes. Mutations in the genes may change virulence of the virus.