CD22分子是免疫球蛋白超家族中唾液酸黏附素家族的一个成员，同时也是B细胞表面抑制性辅助受体之一，它与B细胞的发展、分化和功能有着密切的关系。CD22限制性地表达于成熟B细胞和大多数B淋巴瘤细胞表面。以CD22为靶点，进行肿瘤免疫治疗已经成为免疫研究热点之一。此文主要阐述了CD22的生物学特征、生物学功能以及CD22分子在肿瘤靶向治疗中的应用。

 CD22, a member of sialoadhesin family of immunoglobulin superfamily (IgSF), is an inhibitory coreceptor of the B cell receptor (BCR) and plays a critical role in B cell development, differentiation and function of B cell. CD22 is reported to be restrictedly expressed on the surface of normal mature B lymphocytes and many types of malignant B cells. CD22 has become one of the research hotspots for the treatment of hematological malignancy. This review summarizes the biological features, functions of CD22, and applications of CD22-targeted therapy for non-Hodgkin lymphoma.