人巨细胞病毒（human cytomegalovirus，HCMV）是一种常见的疱疹病毒。在HCMV感染细胞内，表达最早且最丰富的是即刻早期蛋白1（IE1），后者可以影响病毒和细胞启动子的活性，调控HCMV基因表达的时序性，并通过多种途径影响细胞凋亡，还与体内葡萄糖调控蛋白78的表达密切相关。此文对近年来关于IE1蛋白功能研究的最新进展做一综述。

 Human cytomegalovirus (HCMV) is a common herpesvirus. In the infected cells, immediate early protein 1 (IE1) is the earliest and most abundant protein expressed, which influences activity of promoters in the virus and cells, plays a role in apoptosis inhibition, regulates the sequence of gene expression. Also, it is essential for activation of HCMV-mediated glucose regulated protein 78. This article summarizes recent research progress in function of HCMV IE1 protein.