手足口病是一种威胁5岁以下儿童生命健康的传染病，近年来已在亚太地区造成了多次上百万患者发病的大规模暴发，仅在中国大陆，自2008年以来，每年发病人数就超过百万，死亡数百人。然而，由于肠道病毒71型（EV71）是导致重症和死亡病例的主要病原体，而其致病机制尚不清楚，目前尚无有效的治疗性药物，因此EV71疫苗研究成为迫切需要解决的问题。此文就EV71灭活疫苗研究进展进行综述。

Hand-foot-and-mouth disease (HFMD) is a life-threatening infectious disease of children under 5 years old. In recent years, major outbreaks of HFMD caused by enterovirus 71 (EV71) have emerged in the Asia-Pacific region, and have resulted in millions of cases and hundreds of deaths each year in China since 2008. Because EV71 is one of the main pathogens of HFMD resulting in severe diseases and death, the pathogenesis of HFMD is still unclear, and no effective therapeutic drugs for EV71 infection are currently available, development of vaccines against EV71 is urgently needed. This review summarizes research progress of inactivated EV71 vaccines.