泛素-蛋白酶体系统是细胞内蛋白降解的主要途径，目前认为这一系统参与多种炎症和自身免疫病的发生，因此，通过阻断泛素调节蛋白降解成为治疗自身免疫病的新方法。此文就蛋白酶体抑制剂硼替佐米治疗自身免疫病的研究进展做一综述。

 The ubiquitin-proteasome system, which is considered to mediate inflammation and autoimmune diseases, is the main way of protein degradation. Thus, blocking of ubiquitin-mediated protein degradation has become a new way for the treatment of autoimmune diseases. This article reviews studies on proteasome inhibitor bortezomib in the treatment of various autoimmune diseases.