乙型肝炎病毒感染所致的慢性肝炎是严重的全球性公共卫生问题，目前使用的药物仅能抑制病毒复制，不能彻底清除病毒。如何有效、全面地激发患者的免疫系统，重建对乙型肝炎病毒的免疫力，可能是消除慢性感染的关键。治疗性乙型肝炎疫苗有望成为新的治疗策略。目前，国内外研究的治疗性乙型肝炎疫苗主要包括蛋白疫苗、多肽疫苗、DNA疫苗和树突状细胞疫苗，此文对疫苗的临床试验进展及其与抗病毒药物联合应用研究进行综述。

 Chronic hepatitis B caused by hepatitis B virus （HBV）is a severe global public health problem. Current anti-viral drugs are effective in suppressing HBV replication but fail to clear the virus in most cases. How to effectively and comprehensively stimulate patients' immune system and reconstruct immunity against HBV may be the key to eliminate chronic infection. Therapeutic HBV vaccine is promising to become a new strategy. A variety of therapeutic HBV vaccines are being developed, including protein, peptide, DNA, and autologous dendritic cell vaccines. The progress of clinical research on the vaccines and their combined application with anti-viral drugs is summarized in this review.