肠道病毒71型（enterovirus 71，EV71）是引起严重手足口病的主要病原体，研发安全有效的疫苗是控制手足口病的关键措施。目前我国（香港、澳门和台湾地区除外）已有3家公司完成了EV71全病毒灭活疫苗的Ⅲ期临床试验，结果显示疫苗在婴幼儿中安全性良好，预防EV71引起手足口病的保护率达到90%以上，预防EV71其他相关疾病的保护率达到80%以上。此文对这些EV71疫苗临床试验情况做一综述。

 Enterovious 71(EV71) is a major pathogen causing severe hand, foot and mouth disease (HFMD). A safe and effective vaccine against EV71 is the critical approach to control the disease. Currently, three companies in China (excluding Hong Kong, Macao and Taiwan) have completed Phase Ⅲ clinical trials of inactivated EV71 whole-virus vaccines. Results of the clinical trials indicate high safety and immunogenicity of EV71 vaccine. Protective efficacies against EV71-associated HFMD and other EV71-associated diseases are over 90% and 80%, respectively. In this paper, the clinical trials of EV71 vaccines are summarized.