T、B淋巴细胞在自身免疫病发生发展中起重要作用，其中肿瘤坏死因子家族的B细胞激活因子(B cell activating factor of the tumor necrosis factor family, BAFF)是B细胞存活和T细胞激活的重要细胞因子，与许多疾病发生发展相关。此文重点介绍BAFF及其受体的结构功能、BAFF与相关疾病以及基于BAFF的靶向治疗。

 T, B lymphocytes serve crucial functions in the pathogenesis of autoimmune diseases. B cell activating factor of the tumor necrosis factor family (BAFF) is an important cytokine in B-cell survival and T-cell activation. BAFF is related to many diseases. This article focuses on structure and function of BAFF and its receptors, BAFF related diseases and targeting treatments based on BAFF.