Abstract:Objective To evaluate the safety of vaccination and the quality of vaccination service in Xishan District of Kunming. Methods Data on suspected cases of Adverse Event Following Immunization (AEFI) in Xishan District from 2014 to 2018 were collected through the China Immunization Program Information Management System. Descriptive methods were used for epidemiological analysis of relevant monitoring indicators and occurrence characteristics. Results A total of 294 cases of AEFI were reported in Xishan District of Kunming from 2014 to 2018. There were case reports in all 10 sub-district offices in the jurisdiction, and no vaccination accident reports. The annual average reported incidence of AEFI was 12.27 per 100 000 doses. 167 cases (56.80% of the reported cases) were general reactions, and the reported incidence rate was 6.97 per 100 000 doses. 79 cases (26.87%) of abnormal reactions. The reported incidence of abnormal reactions was 3.3 per 100 000 doses, and there were no deaths. Abnormal reactions were mainly urticaria, maculopapular rash, allergic rash, measles scarlet fever-like skin rash (66 cases, 0.28/100 000 doses), BCG vaccine causes axillary lymphadenopathy (4 cases, 0.17/100 000 doses), febrile convulsions (3 cases, 0.13/100 000 doses) and thrombocytopenic purpura (3 cases, 0.13/100 000 doses). There were 7 cases of severe abnormal reactions (1 case of lung infection caused by BCG, 3 cases of febrile seizures, 3 cases of thrombocytopenic purpura), and the incidence rate was 0.29/100 000. Conclusions The sensitivity of AEFI monitoring in Xishan District of Kunming is increasing year by year, and the safety of vaccination and the quality of vaccination service are good.