当前新型冠状病毒肺炎（COVID-19）疫情仍在全球大流行，确诊病例和死亡人数仍不断攀升，如何有效控制病毒的传播，降低传染率和死亡率是目前全人类亟待解决的问题。一方面需要快速、可靠、经济的检测方法及时发现新型冠状病毒（severe acute respiratory syndrome coronavirus 2，SARS-CoV-2）感染者，另一方面需要寻找新颖、有效的COVID-19治疗及预防策略。各种基于成簇规律间隔短回文重复序列及其相关蛋白（clustered regularly interspaced short palindromic repeat and associated protein，CRISPR-Cas）系统的新一代基因编辑技术以其快速、便携、经济、高效的特点为COVID-19快速分子诊断提供了解决方案。CRISPR-Cas系统具有可准确识别并降解SARS-CoV-2病毒核酸的特点，为研发针对COVID-19的新型治疗及预防手段提供了一种潜在的技术方案。此文对目前COVID-19诊断及治疗现状进行了分析，对基于CRISPR-Cas系统的COVID-19分子诊断、治疗及预防策略研究及其新进展进行了简述。

The current COVID-19 epidemic is still in a global pandemic, and the number of confirmed cases and deaths continues to rise. How to effectively control the spread of the virus and reduce the infection rate and the mortality rate is an urgent problem for all mankind at present. On the one hand, we need fast, reliable, and economic detection methods to find severe acute respiratory syndrome coronavirus 2（SARS-CoV-2） infection in time. On the other hand, it is necessary to find novel and effective COVID-19 treatment and prevention strategies. A variety of new-generation gene-editing technologies based on clustered regularly interspaced short palindromic repeat and associated protein (CRISPR-Cas) systems provide rapid, portable, economical, and efficient features for rapid genetic diagnosis of COVID-19 solution. The CRISPR-Cas system can accurately recognize and degrade SARS-CoV-2 nucleic acid, which provides a potential technical solution for the development of new treatment and prevention methods for COVID-19. This paper analyzes the current situation of diagnosis and treatment of COVID-19, and briefly describes the research progress of molecular diagnosis, treatment, and prevention strategies of COVID-19 based on CRISPR-Cas system.