IFN-Ⅰ抗病毒效应信号通路研究新进展

田雨 赵俊 陈敬贤 王明丽

doi:10.3760/cma.j.issn.1673-4211.2018.01.009

国际生物制品学杂志 >

2018 , Vol. 41 >Issue 1: 34 - 39

DOI: https://doi.org/10.3760/cma.j.issn.1673-4211.2018.01.009

综述

IFN-Ⅰ抗病毒效应信号通路研究新进展

田雨赵俊陈敬贤王明丽

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230032 合肥，安徽医科大学第一临床医学院（田雨），微生物学教研室（赵俊、陈敬贤、王明丽）

网络出版日期: 2025-08-16

基金资助

国家重点研发计划（2017YFD0500900，2017YFD0501000）；安徽省高等学校省级质量工程项目（2012sjjd014）；安徽省博士后研究人员科研活动经费资助项目（2017B194）

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Recent advances in signaling pathway of IFN-Ⅰantiviral effect

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*The First Clinical Medical College, Anhui Medical University, Hefei 230032, China

Online published: 2025-08-16

Supported by

National Key R&D Program of China (2017YFD0500900, 2017YFD0501000); Provincial Quality Project of Higher Education Institution of Anhui Province (2012sjjd014); Scientific Research Foundation for Postdoctoral Researchers of Anhui Province (2017B194)

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摘要

IFN-Ⅰ作为一种重要的抗病毒药物在临床上日益受到关注，其抗病毒效应的发挥主要通过IFN-Ⅰ及随后的多种抗病毒分子合成，这两步的实现均需依托相应信号通路的信号转导。近年来，人们对几条 IFN-Ⅰ相关的抗病毒信号通路及其相应的调控机制已有深入了解。此文就IFN-Ⅰ主要抗病毒信号通路及其调控机制的最新进展做一综述。

关键词： 干扰素Ⅰ型；信号传导；干扰素刺激基因因子3

本文引用格式

田雨赵俊陈敬贤王明丽 . IFN-Ⅰ抗病毒效应信号通路研究新进展[J]. 国际生物制品学杂志, 2018 , 41(1) : 34 -39 . DOI: 10.3760/cma.j.issn.1673-4211.2018.01.009

Abstract

IFN-Ⅰ is an important antiviral agent increasingly gaining clinical interest. The antiviral effect of IFN-Ⅰis mainly conducted by the production of IFN-Ⅰ and subsequent synthesis of multiple antiviral molecules. Both steps rely on a series of signal transduction of corresponding signal pathways to complete. In recent years, several IFN-Ⅰ-related antiviral signaling pathways as well as corresponding regulatory mechanisms have been revealed. In this paper, the latest progress of IFN-Ⅰ-related anti-viral signal pathway and their regulatory mechanisms is reviewed.

Key words： Interferon type Ⅰ; Signal transduction; Interferon-stimulated gene factor 3

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