肿瘤疫苗包括肽或蛋白疫苗、肿瘤细胞疫苗、抗独特型疫苗、树突状细胞疫苗、DNA疫苗及病毒载体类疫苗等。重组蛋白疫苗是通过对目的抗原基因的重组、构建、表达得到抗原蛋白，最终制备成的疫苗。随着重组技术及表达纯化技术的日益成熟，重组蛋白疫苗为肿瘤免疫治疗研究提供了一种研发思路。此文针对肿瘤抗原的重组蛋白疫苗做一综述。

Tumor vaccines include peptide or protein vaccine, tumor cell vaccine, anti-idiotype vaccine, dendritic cell vaccine, DNA vaccine and viral-vector based vaccine. The recombinant protein vaccine is prepared by the recombination, construction, and expression of target antigen gene. With the development of recombination, expression and purification technologies, recombinant protein vaccine provides a research and development method for tumor immunotherapy study. This article reviews on the recombinant protein vaccine of tumor antigen.