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血浆制品中人细小病毒B19的灭活/去除研究进展

  • 卜凤荣 于军 宿艳笋
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  • 050018  石家庄,河北医科大学科技总公司河北大安制药有限公司研发部(卜凤荣、宿艳笋),供应部(于军)

网络出版日期: 2025-08-16

The progress in research of the inactivation/removal of human parvovirus B19 in plasma-derived products

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  • *Department of Research and Development,Daan Pharmaceutical Ltd.,Science and Technology General Company of  Hebei Medical University, Shijiazhuang 050018, China

Online published: 2025-08-16

摘要

存在于血浆制品中的人细小病毒B19(human parvovirus B19,B19)是传播B19的潜在危险,尤其是B19可经污染的血浆制品的输注而在易感人群中传播。据认为,B19对普通的理化灭活方法有较强的抵抗力。然而,各项研究显示,B19对加热和低pH处理较敏感。因此,可以选择合适的方法来灭活B19。

本文引用格式

卜凤荣 于军 宿艳笋 . 血浆制品中人细小病毒B19的灭活/去除研究进展[J]. 国际生物制品学杂志, 2009 , 32(6) : 320 -323 . DOI: 10.3760/cma.j.issn.1673-4211.2009.06.010

Abstract

 The presence of human parvovirus B19(B19) in plasma-derived products indicates a potential risk of B19 transmission,and especially,B19 may be transmitted by transfusion of the contaminated plasma and plasma-derived products in susceptible individuals.It is believed that B19 is more resistant to common physicochemical inactivation methods.However,the various studies show that B19 is more sensitive to heat and low pH treatment.So suitable methods may be selected to inactivate B19.
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