由B群脑膜炎球菌(Neisseria meningitidis serogroup B, MenB)引起的流行性脑脊髓膜炎是全球重要的公共卫生问题之一。由于MenB荚膜多糖与人体组织具有相似性，以及MenB外膜蛋白抗原具有多样性和复杂性，因此目前尚无有效的MenB疫苗。荚膜多糖修饰疫苗可能是一种解决办法；应用反向疫苗学等方法确认MenB的各种保守抗原是重要的疫苗研究途径；将多种无交叉反应的抗原混合制成疫苗同样是未来的研究方向之一。此文就MenB疫苗的研究进展作一综述。

Epidemic cerebrospinal meningitis caused by Neisseria meningitidis serogroup B (MenB) is one of the most important public health problems throughout the world. Due to similarity between MenB capsular polysaccharide and human tissue,as well as diversity and complexity of MenB outer membrane protein antigen,there is still no effective vaccine. Capsular polysaccharide-modified vaccine is a possible solution. Identification of MenB conserved antigens by novel methods such as reverse vaccinology is an important way for vaccine development. Mixture of many non-cross-reactive antigens is also one of the future directions for vaccine development. The progress in research of MenB vaccine is reviewed in this paper.