全球范围内有超过4亿慢性乙型肝炎病毒携带者，这些患者发展为肝硬化和肝癌的危险性较大。现有疗法不能长期控制大多数患者的病毒复制，而治疗性乙型肝炎疫苗因其独特的优点正成为新的研究热点。此文就治疗性乙型肝炎疫苗的分类及最新研究进展加以综述。

 More than 400 million people in the world are now chronically infected with hepatitis B virus(HBV). For these patients, there is a high risk to develop cirrhosis and hepatocellular carcinoma. Currently available therapies fail to control viral replication for a long time in most patients. Vaccine therapy has recently shown a unique advantage and become the development focus for treatment of patients with chronic HBV infection. This paper reviews the classification and recent research progress of therapeutic HBV vaccines.