最近狂犬病疫苗研究取得重大突破。新型狂犬病减毒活疫苗效力更高而且高度安全，甚至有可能用于狂犬病发病后的早期治疗。这是狂犬病疫苗诞生一百多年来的一个重要里程碑。此文对狂犬病疫苗研究取得的重大突破、决定狂犬病病毒致病性和免疫原性的相关因素及新型狂犬病减毒活疫苗的主要优点作一综述。

There is a great breakthrough in the development of rabies vaccine. These novel live-attenuated vaccines for rabies are very effective and safe, and may even be used as the early treatment at the onset of rabies. These novel vaccines have been recognized as an important milestone since the rabies vaccine was first developed more than 100 years ago. In this review, the breakthrough in the development of rabies vaccine , some related factors determining the pathogenicity and immunogenicity of rabies virus and the advances in the development of these novel live-attenuated rabies vaccines are summarized.