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融合蛋白技术在生物医药领域中的应用

  • 李征 栗克喜
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  • 610023 成都生物制品研究所生物技术研究室

网络出版日期: 2025-08-16

Applications of fusion protein techniques in biopharmaceutical areas

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  • Biotechnique Department, Chengdu Institute of Biological Products, Chengdu 610023, China

Online published: 2025-08-16

摘要

在治疗性药物的研发中,效应分子与人免疫球蛋白IgG1 Fc片段或人血清白蛋白形成的融合蛋白疗效不变,但体内半衰期明显延长、药物耐受性增加、副作用减少。在疫苗研发中,抗原分子与毒素分子或Fc形成的融合蛋白是很好的新型疫苗,并能激发细胞免疫。

本文引用格式

李征 栗克喜 . 融合蛋白技术在生物医药领域中的应用[J]. 国际生物制品学杂志, 2011 , 34(2) : 91 -94 . DOI: 10.3760/cma.j.issn.1673-4211.2011.02.009

Abstract

 In the development of biopharmaceuticals, fusion proteins of effectors and IgG1 Fc fragment or human albumin have the same treatment efficacy as the effectors alone, much prolonged half-life, increased drug tolerance, and decreased side effects. In the studies of vaccines, the fusion proteins of antigens and toxins or IgG1 Fc will become new type of vaccines which can also stimulate T cell response.
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